PRL-8-53 (by. IUPAC-3- [2- [benzyl (methyl) amino] ethyl] benzoate) is a synthetic derivative of benzoic acid and phenethylamine. It was shown that it combats catatonia and ptosis caused by reserpine – a naturally occuring alkaloid that flushes out catecholamines from the central nervous system. Nonetheless, the exact mechanism of this substance is unknown. Study results suggest a positive effect of PRL-8-53 on the activity of the cholinergic and dopaminergic systems, and an inhibiting effect on the activity of the serotonin system.2
Studies with healthy individuals have shown that PRL-8-53 slightly improved the functioning of the working memory, and significantly improved long-term memory, especially in older participants of the study.2,3
Additionally, this compound has a positive effect on mood and an anti-depressant effect.1 Studies on animals have also determined the diastolic effects of PRL-8-53; wherein the spasmolitic activity of PRL-3-53 was three times as much as the activity of papaverine, which is a derivative of drotaverine (No-Spa) - a substance widely used in cases of spastic smooth muscles.1,2
Clinical trials on healthy participants used doses of 5 mg.2
As suggested in patent application, a daily dose is 0.01-4 mg/kg, where the most preverable dose range is 0.05-1.2 mg/kg.1
Lack of data.
Lack of data.
There were no reported side effects in humans, however, studies in rats have shown that at a dose of 160 mg/kg (13-26 mg/kg in higher mammals, including humans) reduces the motor activity by 50%.2
1. Hansl, N. R. Process for hydrolyzing 3-trifluoromethyl phenethylamines. 1–12 (1974).
2. Hansl, N. R. & Mead, B. T. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacol. (Berl). 56, 249–253 (1978).
3. Hansl, N. R. A novel spasmolytic and CNS active agent: 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. Experientia. 30, 271–2. (1974).
No customer comments for the moment.
NO registration required!
If the question you have has not yet been answered here, use the form below to ask something about this addon.
Our website contains objective and reliable information based on current scientific publications. We care about maintaining a high level of quality standards in the articles we publish by keeping our site up-to-date and making sure the information we place on it is clear and transparent. The authors of the website content are scientists from UJ, a neuropsychologist and a chemist.
At Allchemy.eu, professionalism is of our utmost interest. Our team consists of a neuropsychologist, a pharmacist, a chemist, a psychologist, and a physicist. We don't just “do business.” This is our passion and we test all available chemical agents on ourselves, selecting the most interesting ones while discarding those that we deem dangerous or harmful.
Do you value time and comfort? We ship our packages through DPD courier, Polish Post Office, and Inpost post boxes- every day! Orders made before 10 AM are shipped on the same day!
We care about your satisfaction. That is why you can always return an originally sealed product within 30 days of purchase, no reason necessary.
LABORATORY QUALITY TESTING
The products found in our catalog come from tested and trusted sources, are certified, and undergo laboratory analyses- i.e HPLC, GC, TLC; 1 H NMR spectroscopy, IR, AAS, and the physiochemical parameters -temperature melting point, pH, humidity.
Vaccuum packaging protects our chemical agents from the effects of oxygen and air moisture. Oxygen is a very reactive compound that causes the oxidation and breakdown of certain compounds, while water facilitates the development of bacteria and processes of hydrolysis. Thanks to the vaccuum packaging of sensitive compounds, our clients receive top quality products that can also be kept for later use. Nevertheless, it is important to remember to tightly reseal the packaging by removing any air from the bag and precisely closing the seal. This will pay off!