PRL-8-53 (by. IUPAC-3- [2- [benzyl (methyl) amino] ethyl] benzoate) is a synthetic derivative of benzoic acid and phenethylamine. It was shown that it combats catatonia and ptosis caused by reserpine – a naturally occuring alkaloid that flushes out catecholamines from the central nervous system. Nonetheless, the exact mechanism of this substance is unknown. Study results suggest a positive effect of PRL-8-53 on the activity of the cholinergic and dopaminergic systems, and an inhibiting effect on the activity of the serotonin system.2
Studies with healthy individuals have shown that PRL-8-53 slightly improved the functioning of the working memory, and significantly improved long-term memory, especially in older participants of the study.2,3
Additionally, this compound has a positive effect on mood and an anti-depressant effect.1 Studies on animals have also determined the diastolic effects of PRL-8-53; wherein the spasmolitic activity of PRL-3-53 was three times as much as the activity of papaverine, which is a derivative of drotaverine (No-Spa) - a substance widely used in cases of spastic smooth muscles.1,2
Clinical trials on healthy participants used doses of 5 mg.2
As suggested in patent application, a daily dose is 0.01-4 mg/kg, where the most preverable dose range is 0.05-1.2 mg/kg.1
Lack of data.
Lack of data.
There were no reported side effects in humans, however, studies in rats have shown that at a dose of 160 mg/kg (13-26 mg/kg in higher mammals, including humans) reduces the motor activity by 50%.2
1. Hansl, N. R. Process for hydrolyzing 3-trifluoromethyl phenethylamines. 1–12 (1974).
2. Hansl, N. R. & Mead, B. T. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacol. (Berl). 56, 249–253 (1978).
3. Hansl, N. R. A novel spasmolytic and CNS active agent: 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. Experientia. 30, 271–2. (1974).
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