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ALCAR

7,90 €

  •   aids in weight loss
  •  has neuro-protective properties
  •  improves memory and other cognitive functions

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Acetyl-L-carnitine (ALCAR) is an acetyl derivative of L-carnitine, which occurs naturally in the human body where it plays a role in maintaining an optimal balance between acetyl-CoA and CoA, as well as in transporting fatty acids to the mitochondrion, where they are utilized in the production of energy. The acetyl form of carnitine is characterized by its ability to cross the blood-brain barrier, as well as by its higher bioavailability than the traditionally used L-carnitine.1,2

Aids in weight loss

The Mitochondrion plays a role as a sort of energy center of the cell. L-carnitine increases the potential of the mitochondrion in burning fat, that is why preparations containing carnitine, including ALCAR, are often used as diet supplements for weight loss.3

Has neuro-protective properties

Basic studies have shown, that ALCAR inhibits the formation of lipofuscin deposits- the lipid pigment deposited in the cells of various types of tissue, such as the heart and the brain, which plays a role in various aspects of the natural aging process, and is associated with such neurodegenerative diseases as Alzheimers and Parkinson's.4

Has a positive effect on memory and other cognitive functions

Moreover, acetyl L-carnitine also acts as an acetyl group donor in the biosynthesis of acetylcholine thereby increasing the activity of the cholinergic system. This has a positive effect on memory and cognitive function in healthy people as well as elderly people with dementia, or those with a history of alcohol abuse.5–7

Has anti-depressant effects

ALCAR is characterized by its anti-depressant qualities resulting from its positive effect on the activity of the glutamate receptor gene, one of the main neurotransmitters in the central nervous system. The therapeutic effect of ALCAR is able to be felt after 3 days of treatment, whereby the effects of conventional anti-depressant medication appear after up to 2 weeks.8,9

Dosage

A daily dose administered orally is typically between 1500-2000 mg.5

Synergy

Caffeine, Alpha-lipoic acid, choline, choline bitartrate, DMAE, calcium pantothenate, soy isoflavones, CoQ10, alcohol, DHEA

The dose of ALCAR should be lowered, when used with other supplements.

Interaction

Interaction may occur with anticoagulants, such as Acenocoumarol or Warfarin.10

Side effects

  • ALCAR is considered safe for most people. Nevertheless, side effects may occur in the form of nausea, vomiting, indigestion and nervousness. It may also cause a "fish-like" odor of breath, urine, and sweat.  
  • Because of the lack of appropriate studies, ALCAR is not recommended for pregnant or breast-feeding women. 
  • Not recommended for use by people suffering from hypothyroidism and after myocardial.5,10

Bibliography

1. Nałȩcz, K. a., Miecz, D., Berezowski, V. & Cecchelli, R. Carnitine: Transport and physiological functions in the brain. Mol. Aspects Med. 25, 551–567 (2004).
2. Burlina, a P., Sershen, H., Debler, E. a & Lajtha, a. Uptake of acetyl-L-carnitine in the brain. Neurochem. Res. 14, 489–493 (1989).
3. Center, S. a et al. The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine. J. Vet. Intern. Med. 14, 598–608 (2000).
4. Amenta, F., Ferrante, F., Lucreziotti, R., Ricci, a & Ramacci, M. T. Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment. Arch. Gerontol. Geriatr. 9, 147–153 (1989).
5. Acetyl-L-Carnitine Monograph. Altern. Med. Rev. 15, 76–83 (2010).
6. Rump, T. J. et al. Acetyl-l-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radic. Biol. Med. 49, 1494–1504 (2010).
7. Ando, S. et al. Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J. Neurosci. Res. 66, 266–271 (2001).
8. Nasca, C. et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc. Natl. Acad. Sci. U. S. A. 110, 4804–9 (2013).
9. Wang, S.-M. et al. A review of current evidence for acetyl-l-carnitine in the treatment of depression. J. Psychiatr. Res. No–Specified (2014). doi:10.1016/j.jpsychires.2014.02.005
10. WebMD. Acetyl-L-Carnitine. at <http://www.webmd.com/vitamins-supplements/ingredientmono-834-acetyl-l-carnitine.aspx?activeingredientid=834&activeingredientname=acetyl-l-carnitine>
11. http://nootropy.pl/2015/06/17/dzialanie-przeciwdepresyjne-acetylo-l-karnityny-poprzez-indukcje-epigenetycznych-receptorow-mglu2/

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ALCAR

ALCAR

  •   aids in weight loss
  •  has neuro-protective properties
  •  improves memory and other cognitive functions

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RELIABLE INFORMATION

Our website contains objective and reliable information based on current scientific publications. We care about maintaining a high level of quality standards in the articles we publish by keeping our site up-to-date and making sure the information we place on it is clear and transparent. The authors of the website content are scientists from UJ, a neuropsychologist and a chemist.


PRACTICAL EXPERIENCE

At Allchemy.eu, professionalism is of our utmost interest. Our team consists of a neuropsychologist, a pharmacist, a chemist, a psychologist, and a physicist. We don't just “do business.” This is our passion and we test all available chemical agents on ourselves, selecting the most interesting ones while discarding those that we deem dangerous or harmful.


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Do you value time and comfort? We ship our packages through DPD courier, Polish Post Office, and Inpost post boxes- every day! Orders made before 10 AM are shipped on the same day!


HASSLE-FREE RETURNS

We care about your satisfaction. That is why you can always return an originally sealed product within 30 days of purchase, no reason necessary.

LABORATORY QUALITY TESTING

The products found in our catalog come from tested and trusted sources, are certified, and undergo laboratory analyses- i.e HPLC, GC, TLC; 1 H NMR spectroscopy, IR, AAS, and the physiochemical parameters -temperature melting point, pH, humidity.


VACCUUM PACKAGING

Vaccuum packaging protects our chemical agents from the effects of oxygen and air moisture. Oxygen is a very reactive compound that causes the oxidation and breakdown of certain compounds, while water facilitates the development of bacteria and processes of hydrolysis. Thanks to the vaccuum packaging of sensitive compounds, our clients receive top quality products that can also be kept for later use. Nevertheless, it is important to remember to tightly reseal the packaging by removing any air from the bag and precisely closing the seal. This will pay off!