Milk thistle (Sylybum marianum) extract standardized to 80% silymarin content.
Milk thistle is a plant that naturally occurs in Southern Europe and whose therapeutic properties have been known since the ancient times.
Silymarin is a group of flavonolignans with hepatoprotective, antioxidant, and anti-cancer effects. It helps protect the liver from toxins, and also stimulates regenerative processes if the organ is damaged.
Silymarin increases the activity of the DNA-dependent RNA polimerase, which causes an increase in the biosynthesis of proteins in damaged hepatocytes. What is interesting is that silymarin stimulates regenerative processes only in damaged organs while not affecting a healthy liver. Silymarin is commonly recommended for individuals abusing alcohol, drugs, or medicine, suffering from acute hepatitis, especially type B and C, having problems with cholestasis or after being in contact with toxic substances (eg. Pesticides). Silymarin protects the liver from the damage caused by mycotoxins, ethanol, methanol, carbon tetrachloride, carbon disulfide, petroleum hydrocarbons, various types of medicine and plant toxins.2
The antioxidant properties of milk thistle extract have a stabilizing effect on the structure of cell membranes and the intercellular environment. Silymarin can also be used as prophylactically- especially by people living in highly polluted environments, consuming large quantities of highly processed and chemical food, in contact with pesticides, or by individuals who have a genetic predisposition for diseases of the liver or alcoholism.2
Silymarin has a modulating effect on the immune system. It has anti-inflammatory and prostaglandin cyclooxygenase and 5-LOX histamine inhibiting effects.
Silymarin also has anti-diabetic effects and helps protect the pancreas. It lowers the concentration of overall cholesterol and increases the level of protective HDL lipoproteins in the blood.
Silymarin prevents bile stagnation and gall stones. Effectively removes biliary colic (140-280mg Sylimaryny).3
Daily use of silymarin for a few months (150mg/day) may lead to a significant improvement in overall skin condition- especially for individuals with recalcitrant acne (including acne rosacea), psoriasis, allergic diseases.
There is a hypothesis that can also have a beneficial effect in autoimmune diseases.3
The literature also reports on the anti-cancer and anti-rheumatic properties of silymarin.2
200-400 mg, although clinical trials often used daily doses exceeding 800 mg.
Silymarin is one of the most clinically tested hepatoprotective plant substances. It is well tolerated by people. Higher doses may cause a mild laxative effect.
Silymarin may reduce the effectiveness of oral contraceptives.1
1. Korolkiewicz, K., (2008). Fitoterapia chorób przewodu pokarmowego. Panacea Nr 1 (22), s. 14-17.
2. Ptasznik, A., (2004). Rola sylimaryny w zapobieganiu i leczeniu chorób wątroby. Postępy Fitoterapii 4, s. 189-190 http://www.czytelniamedyczna.pl/2561,rola-sylimaryny-w-zapobieganiu-i-leczeniu-chorob-watroby.html
3. Różański, H., Fitoterapia chorób wątroby i pęcherzyka żółciowego. http://espz.pl/materialy/hepar.pdf
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