Resveratrol ((E)-3,5,4'-trihydroksystilben) is a naturally occurring compound from the polyphenol group. It has been the object of great interest for the past 10 years due to its high therapeutic potential- especially in cases of cardiovascular disease, viral infections, cancers, and neuro-degenerative processes.10,4 Being found in grape skins, resveratrol makes its way into red wine; thus being considered the secret to a long life for the French. The extract is taken from the rich in Resveratrol plant- Poygonum cuspidatum- or Japanese Knotweed.
Resveratrol has strong antioxidant characteristics- combats oxidative stress by eleminating free radicals (reactive forms of oxygen). Oxidative stress can lead to many neurodegenerative diseases such as Huntington's, Parkinson's, Wilson's, or Alzheimer's).5 That is why it is extremely important to supply the human body with antioxidants. Polyphenols, such as Resveratrol, have a higher reduction potential than vitamin C (ascorbic acid).2
Randomized, double-blind studies have shown that resveratrol significantly increased blood flow in the brain- the strength of the effect was dose-dependent (250mg, 500mg, and a placebo were used in these studies).7
Inflammation in the nerve cells is an important contributor to the onset of neurological diseases.14 Overactivity of inflammatory markers (microglia) can lead to irreversible damage to the nerve cells. Resveratrol acts as a neuroprotectant by inhibiting microglia.14
Resveratrol enhances the synthesis of nitric oxide, inhibiting platelet aggregation and lowering LDL cholesterol; thus having a protective effect on the cardiovascular system.8 Studies with animals have shown that resveratrol protects the heart from ischemia-reperfusions, lowers blood pressure and reduced cardiac hypertrophy in animal hypertension, as well as slows down the development of atherosclerosis.9
Despite there being many well-documented health benefits of resveratrol, how it exactly works is still not fully understood. Resveratrol inhibits cAMP- dependent phosphodiesterase, generating a cascade of processes that ultimately modulate the activity of AMPK, SIRT1, PGC-1α.11
Resveratrol has chemopreventive features- helps in preventing various types of cancer (i.e. skin cancer), activates deacetylase sirtuins and extends the life of lower organisms.1 Resveratrol effectively combats various viral infections such as herpesviridae- especially herpes simplex virus HSV – 1, HSV -2 labial (face, mouth) and genitals (Herpes simplex virus), Varicella zoster virus (VZV), cytomegalovirus HCMV (human cytomegalovirus), Epstein-Barr virus (EBV); retro viruses such as HIV-1 and HTLV-1 (Human T-lymphotropic virus type 1, human T-cell lymphotrophic virus-1), polyomavirus; Influenza A virus (Influenza A).3
Resveratrol is poorly soluble in water, sensitive to light and high temperature.10
The biological activity of resveratrol may be limited by poor absorption or rapid metabolism, it seems its methylated analogs are more pharmacologically effective such as. Pterostilbene [3,5-dimethoxy-4'-hydroxy-trans-stilbene].6
NO registration required!
If the question you have has not yet been answered here, use the form below to ask something about this addon.
Our website contains objective and reliable information based on current scientific publications. We care about maintaining a high level of quality standards in the articles we publish by keeping our site up-to-date and making sure the information we place on it is clear and transparent. The authors of the website content are scientists from UJ, a neuropsychologist and a chemist.
At Allchemy.eu, professionalism is of our utmost interest. Our team consists of a neuropsychologist, a pharmacist, a chemist, a psychologist, and a physicist. We don't just “do business.” This is our passion and we test all available chemical agents on ourselves, selecting the most interesting ones while discarding those that we deem dangerous or harmful.
Do you value time and comfort? We ship our packages through DPD courier, Polish Post Office, and Inpost post boxes- every day! Orders made before 10 AM are shipped on the same day!
We care about your satisfaction. That is why you can always return an originally sealed product within 30 days of purchase, no reason necessary.