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Bacopa monnieri 50% ekstrakt View larger

Bacopa monnieri 50% extract

8,85 €

  •   reduces stress, symptoms of depression, and anxiety
  •  improves intellectual processes
  •  slows the aging process

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Bacopa monnieri is a herb belonging to the Scrophulariaceae family. This plant grows in moist regions of southern India and South-east Asia, although it can also be found in Australia and both Americas. In India, it is known under the name of Brahmi or Jalanimba, and has been used in traditional Ayurvedic medicine for centuries, where it was classified as Medhya Rasayanas- bringing rejuvenation, clarity, and peace of mind.1,2 According to Ćaraki, an ancient doctor and ayurvedic sage, Brahmi is an effective substance for enhancing brain activity, increasing one's thinking and concluding abilities, recommended as a panaceum for anxiety, cognitive impairment, and lack of concentration. Both the whole plant and its extracts, as well as its isolated steroidal saponins which are the main active substances contained in Bacopa monnieri, have been tested in many laboratories and numerous scientific papers have confirmed that Brahmi exhibits nootropic, neuroprotective and anxiolytic effects.1,3

Brahmi is a natural adaptogen, supporting the body's resistance to stress and trauma, and helping it adapt to adverse environmental conditions. The anxiolytic effects of Bacopa monnieri extracts have been confirmed by many independent research groups. Unlike many conventionally used anxiolytics, such as benzodiazepines (diazepam, lorazepam), Brahmi does not impair short-term memory and cognitive functions, and shows quite the opposite characteristics - a positive effect on cognitive abilities and memory.3

Studies on animals have shown that Bacopa monnieri extracts, through a series of complex molecular effects on the brain, including the induction of 5-HT and serotonin synthesis, cholinergic activation, has a positive effect on learning and memory.Long-term (at least 4 weeks) supplementation of Brahmi increases dendrite development in the nerve cells of the hippocampus- the structure responsible for creating long-term memory traces.5 Studies on healthy humans have shown that after a 12 week treatment, a significant improvement in the speed at which visual information was processed, in verbal learning, and in the memory of new information.3,6 Similar Results were obtained in studies on the elderly, who complained about memory impairment as a result of old age. The effectiveness of Brahmi was confirmed in therapies on people with attention and memory impairment, with hyperactivity and ADHD.1,2 This plant also exhibits anti-depressant effects comparable to trycyclic anti-depressant medication.8,9

Preparatons with Brahmi show anti-oxidative effect, which results from the presence of phenolic compounds and a triterpenoid fraction. These compounds neutralize free radicals, and simulatenously slow down the aging process. Additionally, they increase the activity present in enzyme cells, which are responsible for the protection against oxidative stress. Clinical trials have shown that alcoholic extracts of Bacopa monnieri reduce the toxic effects of aluminum compounds, which cause the deposit of amyloid proteins, in turn leading to neurodegenerative diseases.2,10 These extracts also inhibit the deposition of lipofuscin, which are aging markers responsible for, among other things, the appearance of liver spots on the skin.2 Studies on animal models of Alzheimer's disease have shown that, through the improvement of brain circulation, counteraction of oxidative stress, and the modulation of various neurotransmitters (including acetylcholine, serotonin, catecholamine, GABA and glutamate), Bacopa monnieri reduces memory dysfunction and protects hippocampal neurons against degeneration.11

Temporal lobe epilepsy is caused by abnormal activity of GABA-ergic interneuron degeneration, responsible for synthesizing GABA, and GABA receptor density decrease in the postsynaptic membrane within the hippocampus, which plays an important role in epileptogenesis.12 It was proven that bakozide A has a positive effect on the changes in expression of various subunits of GABA and glutamate receptors in the hippocampus, striatum and cortex, and together with the other glycosides contained in Brahmi protects GABAergic interneurons from degeneration.12–16

Laboratory studies on animal models of temporal lobe epilepsy have shown that, an increased activity of the GABA-ergic and glutamate systems in the striatum and hippocampus counteracts the spreading of sudden bioelectrical discharges from cortical areas to the structures deep within the brain. Additionally, changes in the expression of GABA receptors in the cerebral cortex reduce the frequency of formation of this discharge.12,15,16

Extracts of Bacopa monnieri reduce the synthesis of pro-inflammatory prostaglandins, therefore exhibiting anti-inflammatory and antiallergic effects. Due to the diastolic effect on bronchi, Brahmi is also used for various ailments of the respiratory system in Hindu tradition.3

Additionally, it was confirmed that this plant has anti-bacterial and anti-fungal properties, and seems to have a preventive and therapeutic effect in cases of stomach ulcers caused by alcohol and the Heliobacter pylori bacteria.2,3,17

Dosage

A typical dose of the standardized extract of 50% bakozides is 300 mg per day in a single dose or two doses of 150 mg. After 12 weeks of supplementation with extracts of Bacopa monnieri, it is recommended to take a several weeks break. Brahmi was consumed with ghi, a type of clarified butter, in Indian traditions. Because of the possibility of nausea, stomach cramps and diarrhea it is not recommended to take an extract of Bacopa monnieri on an empty stomach.

Synergy

  • Curcumin18
  • Green tea catechins18
  • Milk thistle18
  • Ashwagandha (Withania somnifera)18
  • Clitoria ternatea18
  • Asparagus18

Interaction

  • Yohimbine has an antagonistic effect to Bacopa monnieri.19
  • Extracts of Bacopa monnieri increase the level of T3 (triiodothyronine) hormones and T4 (thyroxine). Therefore, the preparation should not be used by people with hyperthyroidism.20

Side effects

Practically no side effects were noted in clinical trials using Bacopa monnieri extracts. This supplement is considered safe and well tolerated by humans. The most commonly reported side effects include an increased intestinal motility and ailments of the digestive system (nausea, diarrhea). Much less frequently reported were headaches and rashes.7,21

Storage

At a temperature of 40-60°C bakozides slowly degrade, while at 80°C bakozide content in the formulation decreases drastically. Extracts should be stored at a temperature not higher than 30°C, preferably in a dark and cool place.22

 

Bibliography

1. Rai, D. et al. Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacol. Biochem. Behav. 75, 823–830 (2003).
2. Łojewski, M., Muszyńska, B. & Sułkowska-Ziaja, K. Bacopa monnieri L. Pennell– roślina o wielokierunkowym działaniu leczniczym. Postępy Fitoter. 2, 84–89 (2014).
3. Russo, A. & Borrelli, F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine 12, 305–317 (2005).
4. Charles, P. D., Ambigapathy, G., Geraldine, P., Akbarsha, M. A. & Rajan, K. E. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation. J. Ethnopharmacol. 134, 55–61 (2011).
5. Vollala, V. R., Upadhya, S. & Nayak, S. Enhanced dendritic arborization of hippocampal CA3 neurons by Bacopa monniera extract treatment in adult rats. Rom. J. Morphol. Embryol. 52, 879–886 (2011).
6. Stough, C. et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 156, 481–484 (2001).
7. Raghav, S., Singh, H., Dalal, P. K., Srivastava, J. S. & Asthana, O. P. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J. Psychiatry 48, 238 (2006).
8. Zhou, Y. et al. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. J. Nat. Prod. 70, 652–655 (2007).
9. Sairam, K., Dorababu, M., Goel, R. K. & Bhattacharya, S. K. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9, 207–211 (2002).
10. Jyoti, a & Sharma, D. Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain. Neurotoxicology 27, 451–457 (2006).
11. Uabundit, N., Wattanathorn, J., Mucimapura, S. & Ingkaninan, K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J. Ethnopharmacol. 127, 26–31 (2010).
12. Mathew, J., Gangadharan, G., Kuruvilla, K. P. & Paulose, C. S. Behavioral Deficit and Decreased GABA Receptor Functional Regulation in the Hippocampus of Epileptic Rats: Effect of Bacopa monnieri. Neurochem. Res. 36, 7–16 (2011).
13. Mathew, J., Balakrishnan, S., Antony, S., Abraham, P. & Paulose, C. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. J. Biomed. Sci. 19, 25 (2012).
14. Krishnakumar, A., Abraham, P. M., Paul, J. & Paulose, C. S. Down-regulation of cerebellar 5-HT2C receptors in pilocarpine-induced epilepsy in rats: Therapeutic role of Bacopa monnieri extract. J. Neurol. Sci. 284, 124–128 (2009).
15. Kral, T. et al. Down-regulation of mGluR8 in pilocarpine epileptic rats. Synapse 47, 278–284 (2003).
16. Mathew, J., Soman, S., Sadanandan, J. & Paulose, C. S. Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: Effect of Bacopa monnieri and bacoside-A. J. Ethnopharmacol. 130, 255–261 (2010).
17. Sairam, K., Rao, C. V, Babu, M. D. & Goel, R. K. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. 8, 423–430 (2001).
18. Velmurugan, K., Alam, J., McCord, J. M. & Pugazhenthi, S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic. Biol. Med. 46, 430–440 (2009).
19. Jagtap, A. & Bhaskar, M. Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monniera. Int. J. Ayurveda Res. 2, 2 (2011).
20. Kar, A., Panda, S. & Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J. Ethnopharmacol. 81, 281–285 (2002).
21. Pravina, K. et al. Safety evaluation of BacoMindTM in healthy volunteers: A phase I study. Phytomedicine 14, 301–308 (2007).
22. Phrompittayarat, W. et al. Stability Studies of Saponins in Bacopa monnieri Dried Ethanolic Extracts. Planta Med. 74, 1756–1763 (2008).

DISCLAIMER
Allchemy.eu is a distributor of chemical substances of the highest quality, intended solely for research. The information provided in the description has not been confirmed by GIF, GIS, or EFSA and should not be used to treat, diagnose, or prevent any disease. Our sevice is inteded for adults only and we are not responsible for the inappropriate use of our products.

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Bacopa monnieri 50% extract

Bacopa monnieri 50% extract

  •   reduces stress, symptoms of depression, and anxiety
  •  improves intellectual processes
  •  slows the aging process

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