Phenylpiracetam is a derivative of piracetam (the first synthetic nootropic); which, due to its additional phenyl group, gained lipophilicity and thus increased its absorption capacity.1 Studies have also shown a stronger anti-amnesic and neuroprotective effects in comparison to piracetam, as well as additional psychostimulating features,2,3 increasing physical endurance and resistance to cold. Phenylpiracetam, because of its chiral center, is present in an enantiomeric form or as a racemic mixture.5
Phenylpiracetam has undergone a number of clinical trials, which showed the potential of the substance in cognitive disorders of various natures (mechanical injuries, organic changes and cognitive disorders associated with states of depression, epilepsy, and stroke) Studies on animals proved that phenylpiracetam has a positive effect on cognitive function in healthy individuals as well. Its influence on cognitive functions is related to its effect on acetylcholine and NMDA receptors which play a key role in cognitive processes.8
Studies on phenylpiracetam have yielded positive results in the case of its use as a treatment for depression related to cognitive decline.6 The studies also showed a decrease in symptoms of depression not related to cognitive function.8
Phenylpiracetam exerts increasing physical activity and exercise capacity8 as well as prevents the development of fear, phobia, and sluggishness when subjected to immunological stress.10
The doses administered during studies were between 100 and 200mg 2-3 times per day with a maximum dose of 200-600mg. The halflife of Phenylpiracetam is around 3-5 hours, and crosses the blood-brain barrier roughly about 30 minutes after administration.6,9
Sulbutiamine, alpha-GPC, cytocholine, choline bitartrate, ALCAR, calcium pantothenate.
Some sources suggest that phenylpiracetam may cause sleeplessness due to its psychostimulant effects. Individuals with liver, kidney, blood pressure problems, those suffering from atherosclerosis, those with a tendency toward having allergic reactions to nootropic preparations from the 2-pirolidon group, pregnant or breast-feeding women should not participate in studies on Phenylpiracetam.11
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