Pterostilbene is a naturally occurring compound from the stilbene group. It is similar in structure and effect to resveratrol, though it has 2 methoxy groups in place of the hydroxyl group- because of this, pterostilbene is more biologically active (easier to absorb).
Pterostilbene occurs naturally in berries, blueberries, and grape plants. It is a very promising compound, despite it being studied much less than resveratrol.
There is a lot of evidence suggesting that pterostilbene not only has great therapeutic potential in the case of many neurological, cardiovascular, neoplasmic, metabolic (diabetes), and hematologic diseases, but may also help in preventing them from occuring.2,3
Pterostilbene reducses oxidative stress caused by free oxygen radicals which damage cell tissue and play an important role in the pathogenesis of many diseases. Pterostilbene increases the expression of very important antioxidant enzymes - catalase, glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD).2 These enzymes generate an integrated antioxidant protection system for the body and allow it to maintain a stable balance.
Due to its high antioxidant effects, pterostilbene has a neuroprotective and anti-inflammatory effect. Studies suggest that pterostilbene can decrease the negative effects of injuries and strokes, and may be beneficial for the elderly. Above all, pterostilbene can have improve cognitive and mental functions and can slow down the progression of various neurodegenerative diseases such as Alzheimer's. Additional clinical studies are necessary on the effects of pterostilbene on individuals with neurodegenerative injuries, strokes, and other forms of severe dementia.2
Pterostilbene has a positive effect on the cardiovascular system, reduces the risk of heart attack, has an antiatherogenic effect- reducing the amount of “bad” cholesterol LDL and increasing the amount of “good” cholesterol HDL.5
Many studies confirm the positive effect of pterostilbene on cognitive functions. It was shown that administering pterostilbene to old rats significantly improved their performance in motor and cognitive tasks- this effect was dose dependent. Moreover, an increased concentration of pterostilbene in the hippocampus correlated positively with improved test results in working memory tasks. Research suggests that pterostilbene may be involved in the modulation of neuronal plasticity.2
Pterostilbene shows to have a significant anti-neoplasmic effect- especially regarding breast, esophagus, stomach, colon, liver, pancreas, and prostate cancer, which comprises a lower rate of proliferation, induction of apoptosis, changes in cell cycle and inhibition of metastases.2,3,7,8
Pterostilbene has an analgesic effect,5 and can also lower blood sugar levels.
Pterostilbene is a compound that is relatively safe for humans. Doses of 250 mg/day (divided into 2 portions of 125 mg) were used in toxicological studies.6
Some studies used doses of 200-400 mg.
People that eat large amounts of berries and blueberries have a lower risk of cancer, degenerative diseases, diabetes, and heart disease.
This product is not labeled as a diet supplement in Poland. The information provided in the description has not been confirmed by GIF, GIS, or EFSA and should not be used to treat, diagnose, or prevent any disease.
The quoted scientific studies cannot be considered unequivocal because of their limited nature and aren't required to reveal the full spectrum of effects of the substance.
Consumer opinions found in the product pages are not the opinions of allchemy.pl and should not be considered as recommendations for the use of the product in question. Allchemy.eu is not responsible for the information found therein.
Always consult a doctor or pharmacist when using a new substance from the nootropic family. Our sevice is inteded for adults only and we are not responsible for the inappropriate use of our products.
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