Selank is a synthetic heptapeptide, and a derivative of the naturally occuring tetrapeptide tuftsin of the sequence- thymol-lysine-proline-arginine. It was first synthesized in the late 90's in the Institute of Molecular Genetics of the Russian Academy of Science by adding the sequence: porline-glycine-proline to the C-terminus of tuftsin.
Studies using Selank have shown its effect on dopamine, serotonin, norepinephrine, and its modulatory effect on the immune system. Additionally, in comparison to tuftsin, adding the sequence proline-glycine-profile significantly increased its activity on the serotoninergic system.
N-Acetyl-Selank is the acetyl form of Selank, acquired by adding an acetyl group to the N-terminus of the compound.
IUPAC Name: N-Acetyl- (2S) -1- [2 - [[(2S) -1 - [(2S) -2 - [[(2S) -1 - [(2S) (2S, 3R) -2-amino-3-hydroxybutanoyl] amino] hexanoyl] -pyrrolidine-2-carbonyl] amino] -5- (diaminometylidenoamino) pentanoyl] pyrrolidine-2-carbonyl] amino] acetyl] pyrrolidine-2-carboxylic acid.
Synonyms: NA-Selank, N-acetyl-Selank, Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro
Nr CAS: N/A
Molar Mass: 794 g/mol
1.Narkevich VB, Kudrin VS, Klodt PM, Pokrovskiĭ AA, Kozlovskaia MM, Maĭskiĭ AI, Raevskiĭ KS."Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study"; Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12.
2.Semenova TP, kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. "Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA"; Eksp Klin Farmakol. 2009 Jul-Aug;72(4):6-8.
3.Tatiana Pavlovna Semenova, M M Kozlovskaia, A V Zuĭkov, L A Andreeva "Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia" Neuroscience and Behavioral Physiology
4.Sarkisova KIu, Kozlovskiĭ II, Kozlovskaia MM. "Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice"; Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Mar-Apr;58(2):226-37.
5.Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI." Immunomodulatory effects of selank in patients with anxiety-asthenic disorders"; Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5.
6. Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, "Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia" Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48.
7.Tatiana Pavlovna Semenova, I I Kozlovskiĭ, N M Zakharova, M M Kozlovskaia "Experimental optimization of learning and memory processes by selank"; August 2010 · Eksperimental'naia i klinicheskaia farmakologiia
8.Tatiana Pavlovna Semenova, M M Kozlovskaya, A V Zuikov, L A Andreeva "Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from Antenatal Hypoxia" February 2008 · Neuroscience and Behavioral Physiology
9.Tatiana Pavlovna Semenova, M M Kozlovskaya, N M Zakharova, A V Zuikov "Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny" December 2007 · Bulletin of Experimental Biology and Medicine · Impact Factor: 0.36
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