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Coluracetam

22,85 €

18,28 €

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Coluracetam belongs to the racetam nootropic chemical family- a group of substances with pro cognitive and neuro-protective properties. It was first synthesized in Japan, where it was tested for its effectiveness in Alzheimer's disease treatment. 

Coluracetam controls the flow to the cholinergic neuron,3 which in turn is vital in the synthesis of acetylcholine, a key neurotransmitter responsible for memory. The proper functioning of the cholinergic system is necessary for memory traces to appear in the brain.2

Mechanism of action

Coluracetam's mechanism of action differs from the mechanisms of the other substances from the racetam family (i.e piracetam). It affects the so-called high affinity choline uptake (HACU) process, which can be described as a “narrow throat” in the process of acetylcholine production. Increasing the effectiveness of this process translates into the increased activity of the acetylcholinergic neuron activity.3

Biological activity

Coluracetam is a relatively new substance, hence adequate testing on humans is in progress. It has been tested; however, for its potential usefulness in various disorders such as Generalized Anxiety Disorder or depression.

Studies on animals suggest that Coluracetam's possible mechanism increases the general amount of acetylcholine in the hippocampus- the structure whose contribution is vital in the appearance and evocation of memory traces.3

Dosage

Caution! Coluracetam is a very potent substance whose doses are measured in micrograms (ug)! Doses between 300 and 3000 micrograms per kg body mass have been used in studies on animals. In humans- between 48 and 480 ug per kg body mass.

The best results have been obtained with doses from 5 to 10mg.

 

Bibliography

1. Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs. Drugs, 70(3), 287-312.
2. Hasselmo, M. E. (2006). The role of acetylcholine in learning and memory. Current opinion in neurobiology, 16(6), 710-715.
3. Murai, S., Saito, H., Abe, E., Masuda, Y., Odashima, J., & Itoh, T. (1994). MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. Journal of Neural Transmission/General Section JNT, 98(1), 1-13.

DISCLAIMER

This product is not labeled as a diet supplement in Poland. The information provided in the description has not been confirmed by GIF, GIS, or EFSA and should not be used to treat, diagnose, or prevent any disease. 

The quoted scientific studies cannot be considered unequivocal because of their limited nature and aren't required to reveal the full spectrum of effects of the substance. 

Consumer opinions found in the product pages are not the opinions of allchemy.pl and should not be considered as recommendations for the use of the product in question. Allchemy.eu is not responsible for the information found therein. 

Always consult a doctor or pharmacist when using a new substance from the nootropic family. Our sevice is inteded for adults only and we are not responsible for the inappropriate use of our products.  

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Coluracetam

Coluracetam

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Our website contains objective and reliable information based on current scientific publications. We care about maintaining a high level of quality standards in the articles we publish by keeping our site up-to-date and making sure the information we place on it is clear and transparent. The authors of the website content are scientists from UJ, a neuropsychologist and a chemist.


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